Alcoholic Cardiomyopathy: Overview, Cardiac Effects of Alcohol, Quantity of Alcohol Intake in Cardiac Disease

Alcoholic Cardiomyopathy: Overview, Cardiac Effects of Alcohol, Quantity of Alcohol Intake in Cardiac Disease

alcoholic cardiomyopathy is especially dangerous because

Completely abstaining from alcohol is the key recommendation if you have alcohol-induced cardiomyopathy. Your healthcare provider will likely recommend that you also focus on improving your alcoholic cardiomyopathy is especially dangerous because diet in ways that help your heart. This usually involves limiting your sodium (salt) and cholesterol intake and ensuring you are getting a diet that provides all essential nutrients.

alcoholic cardiomyopathy is especially dangerous because

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In addition to the assessment of the status of the coronary arteries, cardiac catheterization may help obtain useful information regarding cardiac output, the degree of aortic or mitral valvular disease, and cardiac hemodynamics and filling pressures. Importantly however, remember that much of this information can be derived or inferred from the results of noninvasive testing. The only way to cure alcohol-induced cardiomyopathy is with a heart transplant. However, this is usually not an option because there are so few hearts available from organ donors. For that reason, transplant programs have very strict list requirements to qualify for a transplant and abstaining from alcohol is almost always on those lists. Alcohol-induced cardiomyopathy is a relatively uncommon condition, occurring in about 1% to 2% of people who consume more than the recommended amounts of alcohol.

alcoholic cardiomyopathy is especially dangerous because


  • This influences the maintenance of cardiac geometry and contractile function, increasing the development of ACM [121].
  • Although the severity of histological alterations on endomyocardial biopsy correlates with the degree of heart failure in one of our studies, biopsy is not in common use for prognostic purposes [117].
  • Furthermore, there are conflicting data among studies regarding the prognosis of the condition, with some showing overall mortality near 60% and others showing a mortality rate of only 19% (Table ​(Table11).

In these studies, haemodynamic and echocardiographic parameters were measured in individuals starting an alcohol withdrawal program. The findings were analysed taking into account the amount and chronicity of intake and they were compared with the same parameters measured in a control group of non-drinkers. Alcoholic cardiomyopathy (ACM) is a heart disease that occurs due to chronic alcohol consumption. It is a type of dilated cardiomyopathy since it involves dilation or enlargement of one of the heart’s chambers. After myocyte apoptosis or necrosis, the heart tries to repair and regenerate this tissue damage [39,123], but the heart regenerative capacity is low as a result of the ethanol aggressive damage and develops ineffective repair mechanisms such as progressive fibrosis [124,125].

  • Markers such as ethyl sulphate, phosphatidyl ethanol, and fatty acid ethyl esters are not routinely done.
  • In addition, it provides information not only on overall heart size and function, but on valvular structure and function, wall motion and thickness, and pericardial disease.
  • However, cardiac apoptosis may also develop independently of the mitochondrial pathway [115] through the extrinsic pathway, which involves cell surface death receptors [116].
  • Alcoholic cardiomyopathy (ACM) is a cardiac disease caused by chronic alcohol consumption.
  • It is distributed worldwide, with easy social access, and is pleasant when consumed, with positive sensations of welfare, but its negative effects, which include depressive and damaging noxious health effects, are reserved for later.

Pathological Aspects of ACM

  • Measuring blood alcohol concentration in an acute intoxication gives baseline information but does not permit deductions to chronic misuse.
  • Abstinence is the preferred goal, although controlled drinking may still improve cardiac function.
  • This activity examines when this condition should be considered on differential diagnosis.
  • Cardiac catheterization in these patients may reveal normal coronaries or mild coronary artery disease not significant enough to explain the extent of myocardial dysfunction.
  • Electron microscopy reveals mitochondrial enlargement and disorganization, dilatation of the sarcoplasmic reticulum, fat and glycogen deposition, and dilatation of the intercalating discs.

Prompt treatment can help prevent the disease from getting worse and developing into a more serious condition, such as congestive heart failure (CHF). In the Caerphilly prospective heart disease study, platelet aggregation induced by adenosine diphosphate was also inhibited in subjects who drank alcohol [99]. Assessing differences between various forms of alcoholic beverages it should be noted that resveratrol leads in vitro to platelet inhibition in a dose-dependent manner [100] and has shown effects on all-cause mortality in a community-based study [101]. Polyphenols of red barrique wines and flavonoids have been shown to inhibit endothelin-1 synthase [102] and PDGF-induced vasoproliferation thus also contributing to cardiovascular protection [103]. The beneficial heart wine as universal remedy in medieval ages by Hildegard von Bingen [11] found its later correlates in many observations at the beginning of modern medicine when coronary artery disease (CAD) and its risk factors and symptoms received more attention. Heberden [89] described angina so elegantly in 1786 and also added that ”considerable relief“ through ”wine and spirituous liquors“ could be expected.

Cardiac Catheterization

  • Atrial fibrillation should be controlled with chronotropic drugs such as digoxin or diltiazem and anticoagulant treatment to avoid arterial embolisms [60,145].
  • For some people, a combination of factors could also lead to a weakened heart.
  • Since those initial descriptions, reports on several isolated cases or in small series of patients with HF due to DCM and high alcohol intake have been published[15-17].
  • Acetaldehyde is a potent oxidant and, as such, increases oxidative stress, leading to the formation of oxygen radicals, with subsequent endothelial and tissue dysfunction.

Clinical work-up for alcoholic cardiomyopathy

alcoholic cardiomyopathy is especially dangerous because

How common is this condition?

Cardiac Effects of Alcohol

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